In Situ CAR Therapy Using oRNA™ Immunotropic Lipid Nanoparticles
Time: 11:00 am
day: Day One
Details:
- Developing a simplified strategy to produce circular RNA (oRNA) and improve durability of CAR expression over conventional mRNA in immune cells
- Engineering immunotropic lipids to deliver LNPs to immune cells for release of immunoquiescent, unmodified oRNA
- Sharing how our expression screening platform (FoRCETM) has yielded novel IRESs that elevate CAR expression and drive significant improvements in tumor regression (in vivo
