Improving Ex Vivo Immune Cell Engineering Using LNP-Mediated Delivery of CRISPR/Cas9 mRNA & sgRNA
Time: 11:30 am
day: Day One
Details:
- Discussing how LNPs can be used to efficiently deliver mRNA to T-cells and other immune cell types with minimal toxicity
- Developing LNP mediated delivery of CRISPR/Cas9 to achieve high editing efficiency and improved phenotype and potency of TCR-T and CAR-T cells
- Achieving sequential editing of T-cells with LNPs to enable multiplex editing with minimal to no translocations across target genes
